MTESE is a surgical procedure that involves opening the testis and using the magnification offered by the surgical microscope, the seminiferous tubules are carefully studied. The surgeon will search for and retrieve the best-looking and healthiest tissues avoiding the removal of unnecessary testicular fragments and hence preserving the volume of the testis. Retrieved tissues are then sent for analysis and exploration for presence of sperms to be used ultimately by assisted reproduction. This technique may result in higher success rates compared to other forms of testicular biopsy. Improved results are attributed to the magnification power offered by the surgical microscope that significantly improved sperm retrieval rates.